Which supplement works better to increase protein synthesis: hmb or leucine?

Ratings at a Glance

Supplement	Effectiveness Rating	Confidence Rating
HMB
Leucine

Effectiveness Rating: HMB vs Leucine

The effectiveness rating is a measure of the supplements' ability to increase protein synthesis. This rating answers the question of whether or not a supplement does what it claims. The evidence backing up hmb is great, while the evidence backing up leucine is good. HMB should be able to increase protein synthesis more effectively, however both supplements should provide positive results.

Confidence Rating: HMB vs Leucine

Another factor to take into account when comparing supplements is the confidence rating. This rating is a measure of how valid each supplement's effectiveness rating is. Remember, the confidence rating is a measure of how much you can trust the effectiveness rating. This rating is based on how many studies are included in the database on a supplement's claims. Ideally, you want a high effectiveness AND confidence rating.

Leucine's confidence rating is higher than hmb's. This means leucine's effectiveness rating from above is more valid. This does not necessarily mean that leucine works better, it simply means the evidence (included in this database) backing up leucine is more established.