Does tryptophan work?

Overall Effectiveness Rating for Tryptophan

The overall effectiveness rating for tryptophan is 2.2 out of 3. This rating means there is some evidence that using tryptophan may lead to positive results. This rating also means that some evidence does not back up all claims. Below you can find individual ratings for specific claims.

Overall Confidence Rating for Tryptophan

There are 4 studies in the database on tryptophan; the confidence rating is 25. A score above 80 means the effectiveness rating for this supplement is reliable. A score under 80 means there is insufficient evidence to ensure a reliable effectiveness rating. Note, this rating is for tryptophan as a whole. There are also individual ratings for the claims below.

Products Containing Tryptophan

Products Containing Tryptophan
Bloom Nutrition Recovery
Nite Burn
Amino Flood EAAs
BCAA/EAA Hydration Intra-Workout
Anabolic EAA
Full list of all 38 products containing Tryptophan.

Individual Claims

The overall ratings above do no necessarily reflect each claim about tryptophan. Individual claims can have higher or lower ratings. For example, some supplements may have a lot of backing for one claim, but be completely useless for another. Click on claims below for more information.

Performance Claims Effectiveness Rating Confidence Rating
improve cycling performance
improve running performance
decrease fatigue

Mental Health Claims Effectiveness Rating Confidence Rating
improve cognitive ability


Title of Study
Effect of L-tryptophan supplementation on exercise performance
Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly patients suffering from mild cognitive impairment
L-tryptophan supplementation can decrease fatigue perception during an aerobic exercise with supramaximal intercalated anaerobic bouts in young healthy men
L-tryptophan supplementation does not improve running performance