Does l-citrulline work?

Overall Effectiveness Rating for L-Citrulline

The overall effectiveness rating for l-citrulline is 1.8 out of 3. This rating means there is some evidence that using l-citrulline may lead to positive results. This rating also means that some evidence does not back up all claims. Below you can find individual ratings for specific claims.

Overall Confidence Rating for L-Citrulline

There are 3 studies in the database on l-citrulline; the confidence rating is 20. A score above 80 means the effectiveness rating for this supplement is reliable. A score under 80 means there is insufficient evidence to ensure a reliable effectiveness rating. Note, this rating is for l-citrulline as a whole. There are also individual ratings for the claims below.

Products Containing L-Citrulline

Products Containing L-Citrulline
Prewrkt Extreme
SuperPump MAX
R3P Pre Workout
Impact Pump
Full list of all 90 products containing L-Citrulline.

Individual Claims

The overall ratings above do no necessarily reflect each claim about l-citrulline. Individual claims can have higher or lower ratings. For example, some supplements may have a lot of backing for one claim, but be completely useless for another. Click on claims below for more information.

Performance Claims Effectiveness Rating Confidence Rating
improve cardiovascular endurance
improve cycling performance
improve muscular endurance
decrease fatigue
improve cycling sprint performance


Title of Study
l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans
Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study
The effect of l-citrulline and watermelon juice supplementation on anaerobic and aerobic exercise performance