Does glutamine work?

What is Glutamine?

Glutamine is one of the conditionally essential amino acids. Under normal circumstances, the body makes enough. In certain instances, such as a critical illness, the body's requirement exceeds its production capability. In these times, the body needs an external (dietary/supplement) source, to meet its needs. Read More


Overall Effectiveness Rating for Glutamine

The overall effectiveness rating for glutamine is 1.9 out of 3. This rating means there is some evidence that using glutamine may lead to positive results. This rating also means that some evidence does not back up all claims. Below you can find individual ratings for specific claims.

Overall Confidence Rating for Glutamine

There are 12 studies in the database on glutamine; the confidence rating is 32. A score above 80 means the effectiveness rating for this supplement is reliable. A score under 80 means there is insufficient evidence to ensure a reliable effectiveness rating. Note, this rating is for glutamine as a whole. There are also individual ratings for the claims below.

Products Containing Glutamine

Products Containing Glutamine
Genius BCAA
BCAA/EAA Hydration Intra-Workout
Pure Rebuild
Full list of all 47 products containing Glutamine.

Individual Claims

The overall ratings above do no necessarily reflect each claim about glutamine. Individual claims can have higher or lower ratings. For example, some supplements may have a lot of backing for one claim, but be completely useless for another. Click on claims below for more information.

Body Composition (weight, muscle, body fat) Claims Effectiveness Rating Confidence Rating
decrease body fat
increase muscle mass
increase weight loss

Protein Synthesis Claims Effectiveness Rating Confidence Rating
decrease protein breakdown

Performance Claims Effectiveness Rating Confidence Rating
improve cardiovascular endurance
improve high-intensity interval training (HIIT) performance
increase strength
improve cycling sprint performance

Immune Health Claims Effectiveness Rating Confidence Rating
improve immune function

Cardiovascular Health Claims Effectiveness Rating Confidence Rating
lower blood pressure
lower LDL (bad) cholesterol levels
increase HDL (good) cholesterol levels
lower total cholesterol levels
lower triglyceride levels

Recovery Claims Effectiveness Rating Confidence Rating
improve recovery
reduce muscle damage
reduce muscle soreness

General Health Claims Effectiveness Rating Confidence Rating
improve insulin sensitivity
lower fasting glucose


Title of Study
Acute Glutamine Supplementation Does not Affect Muscle Damage Profile after Resistance Training
Effect of glutamine supplementation combined with resistance training in young adults
Effect of glutamine supplementation on cardiovascular risk factors in patients with type 2 diabetes
Effect of L-Glutamine Supplementation on Electromyographic Activity of the Quadriceps Muscle Injured By Eccentric Exercise
Glutamine Supplementation in Recovery From Eccentric Exercise Attenuates Strength Loss and Muscle Soreness
Is Long Term Creatine and Glutamine Supplementation Effective in Enhancing Physical Performance of Military Police Officers?
L-glutamine supplementation: Effects on endurance, power and recovery
Surface Electromyography Assessments of the Vastus medialis and Rectus femoris Muscles and Creatine Kinase after Eccentric Contraction Following Glutamine Supplementation
The Effect of Acute Glutamine Supplementation on Markers of Inflammation and Fatigue During Consecutive Days of Simulated Wildland Firefighting
The effects of glutamine supplementation on performance and hormonal responses in non- athlete male students during eight week resistance training
The effects of oral glutamine supplementation on athletes after prolonged, exhaustive exercise
The Influence of Oral L-Glutamine Supplementation on Muscle Strength Recovery and Soreness Following Unilateral Knee Extension Eccentric Exercise