Does arginine work?

Overall Effectiveness Rating for Arginine

The overall effectiveness rating for arginine is 1.6 out of 3. This rating means there is some evidence that using arginine may lead to positive results. This rating also means that some evidence does not back up all claims. Below you can find individual ratings for specific claims.

Overall Confidence Rating for Arginine

There are 20 studies in the database on arginine; the confidence rating is 40. A score above 80 means the effectiveness rating for this supplement is reliable. A score under 80 means there is insufficient evidence to ensure a reliable effectiveness rating. Note, this rating is for arginine as a whole. There are also individual ratings for the claims below.

Products Containing Arginine

Products Containing Arginine
Code 3
REM Sleep Aid
Nitraflex Burn
Animal Stak
Full list of all 40 products containing Arginine.

Individual Claims

The overall ratings above do no necessarily reflect each claim about arginine. Individual claims can have higher or lower ratings. For example, some supplements may have a lot of backing for one claim, but be completely useless for another. Click on claims below for more information.

Body Composition (weight, muscle, body fat) Claims Effectiveness Rating Confidence Rating
decrease body fat
increase muscle mass
increase weight loss

Protein Synthesis Claims Effectiveness Rating Confidence Rating
decrease protein breakdown

Performance Claims Effectiveness Rating Confidence Rating
improve cycling performance
improve running performance
improve sports performance
improve sprint performance
decrease fatigue
increase strength
improve cycling sprint performance

Hormone Function Claims Effectiveness Rating Confidence Rating
increase levels of growth hormone
increase levels of growth hormone releasing hormone

Recovery Claims Effectiveness Rating Confidence Rating
improve recovery


Title of Study
Acute l-arginine supplementation increases muscle blood volume but not strength performance
Acute l-arginine supplementation reduces the O2 cost of moderate-intensity exercise and enhances high-intensity exercise tolerance
Acute supplementation of L-arginine affects neither strength performance nor nitric oxide production
Arginine and antioxidant supplement on performance in elderly male cyclists: a randomized controlled trial
Arginine and ornithine supplementation increases growth hormone and insulin-like growth factor-1 serum levels after heavy-resistance exercise in strength-trained athletes
Branched-chain amino acids and arginine improve performance in two consecutive days of simulated handball games in male and female athletes: a randomized trial
Branched-chain amino acids and arginine supplementation attenuates skeletal muscle proteolysis induced by moderate exercise in young individuals.
Effects of acute supplementation of L-arginine and nitrate on endurance and sprint performance in elite athletes
Effects of Arginine Supplementation on Post-Exercise Metabolic Responses
Hormonal response to L-arginine supplementation in physically active individuals
Influence of chronic supplementation of arginine aspartate in endurance athletes on performance and substrate metabolism - a randomized, double-blind, placebo-controlled study
L-arginine does not improve biochemical and hormonal response in trained runners after 4 weeks of supplementation
L-Arginine supplementation does not enhance blood flow and muscle performance in healthy and physically active older women
l-Arginine supplementation does not improve muscle function during recovery from resistance exercise
l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans
Oral L-arginine before resistance exercise blunts growth hormone in strength trained males
Pre-exercise arginine supplementation increases time to exhaustion in elite male wrestlers
The acute effects of L-arginine on hormonal and metabolic responses during submaximal exercise in trained cyclists
The effect of l-arginine supplementation on body composition and performance in male athletes: a double-blinded randomized clinical trial
The effect of oral arginine during energy restriction in male weight trainers