Alpha-Ketoisocaproic Acid

Table of Contents

  1. Simple Report
  2. Detailed Report
  3. Overall Effectiveness Rating
  4. Research Rating
  5. Claim Ratings
  6. Dosing
  7. References

Alpha-Ketoisocaproic Acid Simple Report

  • Supplement: Alpha-Ketoisocaproic Acid
  • Supplement Category: leucine metabolites
  • Number of Products Containing Alpha-Ketoisocaproic Acid: 0
  • Effectiveness Rating: 1.4 out of 3
  • Research Rating: 23 (above 80 indicates sufficient research)
  • Number of Studies: 3
  • Number of Claims: 6
  • Effective Dosage Range: 300 milligrams per day

Alpha-Ketoisocaproic Acid Detailed Report

Overall Effectiveness Rating

The overall effectiveness rating for alpha-ketoisocaproic acid is 1.4 out of 3. This rating means there is little to no evidence to back the supplement's use. Using this supplement will not lead to positive results. Note, this effectiveness rating is for alpha-ketoisocaproic acid as a whole; there are also individual ratings for the claims below.

Read more: What is the effectiveness rating?

Research Rating for Alpha-Ketoisocaproic Acid

There are 3 studies in the database on alpha-ketoisocaproic acid; the research rating is 23. A score above 80 means the effectiveness rating for this supplement is reliable. A score under 80 means there is insufficient evidence to ensure a reliable effectiveness rating. Note, this research rating is for alpha-ketoisocaproic acid as a whole; there are also individual ratings for the claims below.

Read more: What is the research rating?

Claim Ratings

The overall ratings above are an average of the individual claim ratings below. Individual claims may have higher or lower ratings compared to the supplement's overall rating. For example, some supplements may have excellent backing for one claim, but be completely useless for another. Click on a claim below for more information.

Performance Claims Effectiveness Rating Research Rating
improve high-intensity interval training (HIIT) performance
improve muscular endurance
improve sports performance

Recovery Claims Effectiveness Rating Research Rating
improve recovery
reduce muscle damage
reduce muscle soreness


The Supplement Database includes 3 studies on alpha-ketoisocaproic acid dosing. These studies indicate an effective dose is 300 milligrams per day. For a more detailed dosing analysis visit: Supplement Dosing for Alpha-Ketoisocaproic Acid.


Title of Study
Exercise-induced muscle damage is not attenuated by beta-hydroxy-beta-methylbutyrate and alpha-ketoisocaproic acid supplementation
Supplementation with beta-hydroxy-beta-methylbutyrate (HMB) and alpha-ketoisocaproic acid (KIC) reduces signs and symptoms of exercise-induced muscle damage in man
The effects of short-term alpha-ketoisocaproic acid supplementation on exercise performance: a randomized controlled trial