Does 5-htp work?

Overall Effectiveness Rating for 5-HTP

The overall effectiveness rating for 5-htp is 1.9 out of 3. This rating means there is some evidence that using 5-htp may lead to positive results. This rating also means that some evidence does not back up all claims. Below you can find individual ratings for specific claims.

Overall Confidence Rating for 5-HTP

There are 5 studies in the database on 5-htp; the confidence rating is 38. A score above 80 means the effectiveness rating for this supplement is reliable. A score under 80 means there is insufficient evidence to ensure a reliable effectiveness rating. Note, this rating is for 5-htp as a whole. There are also individual ratings for the claims below.

Products Containing 5-HTP

Products Containing 5-HTP
REM Sleep Aid
Physique Series Fat Burner Stim-Free
Night Shift
Lights Out Sleep
Full list of all 12 products containing 5-HTP.

Individual Claims

The overall ratings above do no necessarily reflect each claim about 5-htp. Individual claims can have higher or lower ratings. For example, some supplements may have a lot of backing for one claim, but be completely useless for another. Click on claims below for more information.

Body Composition (weight, muscle, body fat) Claims Effectiveness Rating Confidence Rating
increase weight loss

Energy Balance (calories in & calories out) Claims Effectiveness Rating Confidence Rating
increase satiety
decrease calorie intake
suppress appetite

Hormone Function Claims Effectiveness Rating Confidence Rating
decrease cortisol levels

Mental Health Claims Effectiveness Rating Confidence Rating
improve cognitive ability
improve mood

General Health Claims Effectiveness Rating Confidence Rating
lower fasting glucose


Title of Study
Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan
Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients
Oral administration of 5‐hydroxytryptophan (5‐HTP) impairs decision making under ambiguity but not under risk: evidence from the Iowa Gambling Task
The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions: A Pilot Experiment
The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects