Effectiveness Rating for Leucine's Ability to Increase Protein Synthesis

The effectiveness rating is a measure of how well leucine is able to increase protein synthesis. The overall rating for this claim is 2 out of 3. There is some research showing the supplement's ability to deliever on this particular claim is warranted. Using Leucine to increase protein synthesis may lead to positive results.

Confidence Rating for Leucine's Ability to Increase Protein Synthesis

The confidence rating is a mesure of how valid the effectiveness rating is. This rating is based on how many studies are included in the database on this topic.

There are 6 studies in the database on leucine; the confidence rating is 120. A score above 80 means the effectiveness rating for this supplement is reliable. A score under 80 means there is insufficient evidence to ensure a reliable effectiveness rating.

Leucine Dose to Increase Protein Synthesis

Dosage Frequency Daily Total Effectiveness Rating of Dosage
3.42g once daily 3.42g


Title of Study
Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects
Effects of leucine and its metabolite β‐hydroxy‐β‐methylbutyrate on human skeletal muscle protein metabolism
Leucine-enriched essential amino acid supplementation during moderate steady state exercise enhances postexercise muscle protein synthesis
Observations of Branched-Chain Amino Acid Administration in Humans
Co-ingestion of leucine with protein does not further augment post-exercise muscle protein synthesis rates in elderly men.
Hydrolyzed casein and whey protein meals comparably stimulate net whole-body protein synthesis in COPD patients with nutritional depletion without an additional effect of leucine co-ingestion